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What could be the association of IAPV and CCD and protecting bees from IAPV

Ilan Sela1,2; Eyal Maori1; Nitzan Paldi2; Eitan Glick2
1The Hebrew University of Jerusalem, Virus Laboratory, Rehovot 76100, Israel
2Beeologics, LLC, 11800 SW 77th Avenue, Miami, FL 33156, USA

Israeli acute paralysis virus (IAPV, refs 1. 2) has been found to be strongly associated with CCD (3). Segments of the IAPV genome have been shown to incorporate into the bee genome, and bees carrying integrated IAPV sequences become resistant to IAPV (2). We will discuss the postulated possibility (currently under study) that this integration may cause alteration in the bee behavior, leading to CCD. We will also show that Varroa is infected with IAPV, and the viral sequences are integrated into the Varroa genome. We will discuss the aspect that in addition to IAPV, stress is a factor that turn IAPV-carrying bees (in their genome) to develop CCD. We will also show that IAPV can easily and practically be silenced in bees and discuss the outcome of these experiments. 1. E. Maori, E. Tanne, I. Sela, Virology 362, 342 (2007). 2. E. Maori et al., J. Gen. Virol. 88, 3428 (2007). 3. D. Cox-Foster et al., Science 318, 283 (2007).

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